Stuart Little is a 1999 American family comedy film directed by Rob Minkoff. It is loosely based on the novel Stuart Little by E. B. White. It combines live-action and computer animation.
Eleanor Little and Frederick Little and their young son George are intending an adoption. While George is at school, his parents go to an orphanage where they meet and fall in love with a humanoid mouse named Stuart . Despite misgivings from Mrs. Keeper , they adopt Stuart and take him home. However, Stuart is greeted coldly by George, who refuses to acknowledge the mouse as his brother, and the family cat Snowbell , who is disgusted at having a mouse for a "master". Despite Eleanor and Frederick's intentions, Stuart quickly feels like an outsider in the large Little family, especially when the family's unknowing relatives bring Stuart large presents and George snaps at his family, claiming out loud that Stuart is not his brother. When Stuart admits his feelings of loneliness to his parents, they ask Mrs. Keeper to do some background research on Stuart's biological family.
source: Wikipedia
trailer
http://www.youtube.com/watch?v=zPJ6DBYcFbE keywords: family, mouse, friendship